Semmelweis made a breakthrough in early 1800s. He came up with what is known as the hand-washing technique today. Because of his discovery, the mortality rate in women giving birth went down from 18% to 0. Despite that, his discovery never was acknowledged. Instead he died in a mental asylum when he was 47 only.
Garry Tan did a vlog on how breakthroughs can break you and what you can do to avoid that from happening. I’ll leave you to it.